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Antibody Product Overview
| ELK.No | ES15808 |
| Product name | HDA11 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 79885 |
| Human Swiss-Prot | Q96DB2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | HDA11 |
| Fields | >>Neutrophil extracellular trap formation;>>Alcoholism;>>Viral carcinogenesis |
| Gene name | HDAC11 |
| Protein name | HDA11 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 232232 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q91WA3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human HDA11 AA range: 170-220 |
| Specificity | This antibody detects endogenous levels of HDA11 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 38kD |
| Observed band (KD) | |
| Background | This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009], |
| Function | catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,miscellaneous:Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.,sequence caution:Translated as Gln.,similarity:Belongs to the histone deacetylase family.,subcellular location:Predominantly nuclear.,subunit:Interacts with HDAC6.,tissue specificity:Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis., |
| Subcellular location | Nucleus . |
| Expression | Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis. |
Additional Images
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Western blot analysis of lysates from HuvEc cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15808-100
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