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Antibody Product Overview
| ELK.No | ES15816 |
| Product name | HBG1 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3047 |
| Human Swiss-Prot | P69891 |
| Source | Rabbit |
| Isotype | IgG |
| Target | HBG1 |
| Fields | |
| Gene name | HBG1 PRO2979 |
| Protein name | HBG1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human HBG1 AA range: 34-84 |
| Specificity | This antibody detects endogenous levels of HBG1 at Human |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 16kD |
| Observed band (KD) | |
| Background | The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008], |
| Function | developmental stage:Expressed until four or five weeks after birth.,disease:Some gamma variants can cause severe jaundice and cyanosis in premature and new born babies.,function:Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.,online information:Human hemoglobin variants and thalassemias,PTM:Acetylation of Gly-2 converts Hb F to the minor Hb F1.,similarity:Belongs to the globin family.,subunit:Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F). In the case of deletions affecting one or more of the alpha chains the excess gamma chains form homotetramers that exhibit neither Bohr effect nor heme-heme cooperativity (hemoglobin Bart's).,tissue specificity:Red blood cells., |
| Subcellular location | cytosol,hemoglobin complex, |
| Expression | Red blood cells. |
Additional Images
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Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15816-100
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