Français
English
Antibody Product Overview
| ELK.No | ES15871 |
| Product name | GSTM5 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2949 |
| Human Swiss-Prot | P46439 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GSTM5 |
| Fields | >>Glutathione metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Drug metabolism - cytochrome P450;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Platinum drug resistance;>>Pathways in cancer;>>Chemical carcinogenesis - DNA adducts;>>Chemical carcinogenesis - receptor activation;>>Chemical carcinogenesis - reactive oxygen species;>>Hepatocellular carcinoma;>>Fluid shear stress and atherosclerosis |
| Gene name | GSTM5 |
| Protein name | GSTM5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14866 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P48774 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 100912430 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9Z1B2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human GSTM5 AA range: 99-149 |
| Specificity | This antibody detects endogenous levels of GSTM5 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 24kD |
| Observed band (KD) | |
| Background | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:RX + glutathione = HX + R-S-glutathione.,function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,similarity:Belongs to the GST superfamily.,similarity:Belongs to the GST superfamily. Mu family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subunit:Homodimer., |
| Subcellular location | Cytoplasm. |
| Expression |
Additional Images
No image
Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night
No image
No image
No image
: AO-06-ES15871-50
: 10 Items
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package