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Antibody Product Overview
| ELK.No | ES15915 |
| Product name | GRAM4 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 23151 |
| Human Swiss-Prot | Q6IC98 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GRAM4 |
| Fields | |
| Gene name | GRAMD4 DIP KIAA0767 |
| Protein name | GRAM4 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 223752 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8CB44 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human GRAM4 AA range: 304-354 |
| Specificity | This antibody detects endogenous levels of GRAM4 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 64kD |
| Observed band (KD) | |
| Background | GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011], |
| Function | domain:The leucine-zipper is involved in homodimerization.,function:Plays a role as a mediator of e2f1-induced apoptosis in the absence of tp53/p53.,function:Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities.,induction:By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells.,induction:Up-regulated in the mitochondria by E2F1 after addition of 4-hydroxytamoxifen (at protein level).,similarity:Belongs to the TSC |
| Subcellular location | Mitochondrion membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Colocalizes with COX4I1. . |
| Expression | Expressed in lung and in primary lung squamous cell carcinoma (LSCC). |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15915-100
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