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Antibody Product Overview
| ELK.No | ES16145 |
| Product name | GNAI2 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2771 |
| Human Swiss-Prot | P04899 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GNAI2 |
| Fields | >>Rap1 signaling pathway;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>Sphingolipid signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>Axon guidance;>>Apelin signaling pathway;>>Gap junction;>>Platelet activation;>>Leukocyte transendothelial migration;>>Circadian entrainment;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Cholinergic synapse;>>Serotonergic synapse;>>GABAergic synapse;>>Dopaminergic synapse;>>Long-term depression;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Melanogenesis;>>Oxytocin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Relaxin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Cushing syndrome;>>Growth hormone synthesis, secretion and action;>>Gastric acid secretion;>>Parkinson disease;>>Cocaine addiction;>>Morphine addiction;>>Alcoholism;>>Pertussis;>>Chagas disease;>>Toxoplasmosis;>>Human cytomegalovirus infectio |
| Gene name | GNAI2 GNAI2B |
| Protein name | GNAI2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14678 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P08752 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 81664 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P04897 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human GNAI2 AA range: 274-324 |
| Specificity | This antibody detects endogenous levels of GNAI2 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.68% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 38kD |
| Background | The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013], |
| Function | function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1 (By similarity). Interacts with UNC5B., |
| Subcellular location | Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell membrane . Membrane ; Lipid-anchor . Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. |
| Expression | Brain,Cerebellum,Kidney,Lung,Mammary gland,Testis, |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16145-100
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