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Antibody Product Overview
| ELK.No | ES1617 |
| Product name | AIM2 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | AIM2; Interferon-inducible protein AIM2; Absent in melanoma 2 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 9447 |
| Human Swiss-Prot | O14862 |
| Source | Rabbit |
| Isotype | IgG |
| Target | AIM2 |
| Fields | >>NOD-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway |
| Gene name | AIM2 |
| Protein name | Interferon-inducible protein AIM2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q91VJ1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AIM2. AA range:51-100 |
| Specificity | AIM2 Polyclonal Antibody detects endogenous levels of AIM2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 39kD |
| Background | AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in AIM2 may be a cause of microsatellite unstable colon cancers.,function:Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.,induction:By interferon gamma.,similarity:Belongs to the HIN-200 family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 HIN-200 domain.,subunit:Homodimer.,tissue specificity:Expressed in spleen, small intestine, peripheral blood leukocytes, and testis., |
| Subcellular location | Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles. |
| Expression | Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. |
Additional Images
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Immunofluorescence analysis of Hela cell. 1,AIM2 Polyclonal Antibody(red) was diluted at 1:200(4° overnight). HSP70 Monoclonal Antibody(3G10)(green) was diluted at 1:200(4° overnight). 2, Goat Anti Rabbit Alexa Fluor 594 Catalog:RS3611 was diluted at 1:1000(room temperature, 50min). Goat Anti Mouse Alexa Fluor 488 Catalog:RS3208 was diluted at 1:1000(room temperature, 50min).
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Western blot analysis of lysates from 1) HuvEc, 2) Jurkat cells, (Green) primary antibody was diluted at 1:1000, 4°over night, Dylight 800 secondary antibody(Immunoway:RS23920)was diluted at 1:10000, 37° 1hour. (Red) Tubulin β Monoclonal Antibody(5G3) (Immunoway:YM3030) antibody was diluted at 1:5000 as loading control, 4° over night,Dylight 680 secondary antibody(Immunoway:RS23710)was diluted at 1:10000, 37° 1hour.
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Western Blot analysis of HuvEc cells using AIM2 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Western blot analysis of lysates from HUVEC cells, using AIM2 Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES1617-100
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