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Antibody Product Overview
| ELK.No | ES16190 |
| Product name | GGPPS rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 9453 |
| Human Swiss-Prot | O95749 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GGPPS |
| Fields | >>Terpenoid backbone biosynthesis;>>Metabolic pathways |
| Gene name | GGPS1 |
| Protein name | GGPPS |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14593 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9WTN0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 291211 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q6F596 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human GGPPS AA range: 141-191 |
| Specificity | This antibody detects endogenous levels of GGPPS at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 33kD |
| Observed band (KD) | |
| Background | This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010], |
| Function | catalytic activity:Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.,catalytic activity:Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.,catalytic activity:Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.,function:Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.,pathway:Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1.,pathway:Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1.,pathway:Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis; geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1.,simila |
| Subcellular location | Cytoplasm. |
| Expression | Abundantly expressed in testis. Found in other tissues to a lower extent. |
Additional Images
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Western blot analysis of lysates from PC-12 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16190-100
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