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Antibody Product Overview
| ELK.No | ES16271 |
| Product name | GALT2 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form] |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2590 |
| Human Swiss-Prot | Q10471 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GALT2 |
| Fields | >>Mucin type O-glycan biosynthesis;>>Other types of O-glycan biosynthesis;>>Metabolic pathways |
| Gene name | GALNT2 |
| Protein name | GALT2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 108148 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q6PB93 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human GALT2 AA range: 30-80 |
| Specificity | This antibody detects endogenous levels of GALT2 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.194% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 65kD |
| Background | This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014], |
| Function | catalytic activity:UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide.,cofactor:Calcium.,cofactor:Manganese.,domain:The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.,domain:There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.,function:Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked |
| Subcellular location | Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Secreted . Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists. |
| Expression | Widely expressed. |
Additional Images
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Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16271-50
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