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Antibody Product Overview
| ELK.No | ES16313 |
| Product name | FTCD rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 10841 |
| Human Swiss-Prot | O95954 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FTCD |
| Fields | >>Histidine metabolism;>>One carbon pool by folate;>>Metabolic pathways |
| Gene name | FTCD |
| Protein name | FTCD |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14317 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q91XD4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 89833 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O88618 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human FTCD AA range: 157-207 |
| Specificity | This antibody detects endogenous levels of FTCD at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 60kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009], |
| Function | catalytic activity:5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.,catalytic activity:5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH(3).,catalytic activity:5-formyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formyl-L-glutamate.,cofactor:Pyridoxal phosphate.,disease:Defects in FTCD are the cause of glutamate formiminotransferase deficiency [MIM:229100]; also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.,function:Folate-d |
| Subcellular location | Cytoplasm, cytosol . Golgi apparatus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . More abundantly located around the mother centriole. . |
| Expression |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16313-100
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