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Antibody Product Overview
| ELK.No | ES16472 |
| Product name | FHR5 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB |
| Other name | Complement factor H-related protein 5 (FHR-5) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 81494 |
| Human Swiss-Prot | Q9BXR6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FHR5 |
| Fields | >>Complement and coagulation cascades |
| Gene name | CFHR5 CFHL5 FHR5 |
| Protein name | FHR5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human FHR5 AA range: 353-403 |
| Specificity | This antibody detects endogenous levels of FHR5 at Human |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.165% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010], |
| Function | function:Involved in complement regulation.,similarity:Contains 9 Sushi (CCP/SCR) domains.,subunit:Binds C3b in vitro.,tissue specificity:Expressed by the liver and secreted in plasma., |
| Subcellular location | Secreted. |
| Expression | Expressed by the liver and secreted in plasma. |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16472-100
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