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Antibody Product Overview
| ELK.No | ES16651 |
| Product name | EXOSX rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5394 |
| Human Swiss-Prot | Q01780 |
| Source | Rabbit |
| Isotype | IgG |
| Target | EXOSX |
| Fields | >>RNA degradation |
| Gene name | EXOSC10 PMSCL PMSCL2 RRP6 |
| Protein name | EXOSX |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 50912 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P56960 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human EXOSX AA range: 391-441 |
| Specificity | This antibody detects endogenous levels of EXOSX at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 97kD |
| Observed band (KD) | |
| Background | |
| Function | disease:Antibodies against PM/SCL are found in patients with polymyositis and/or scleroderma.,function:Part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Could be an exonuclease (By similarity). Mediates the association of MTR4, C1D and MPP6 wth the exosome and this complex is required for the maturation of 5.8S rRNA. Required for nucleolar localization of C1D.,similarity:Contains 1 3'-5' exonuclease domain.,similarity:Contains 1 HRDC domain.,subunit:Component of the exosome multienzyme ribonuclease com |
| Subcellular location | Cytoplasm. Nucleus, nucleolus. Nucleus. Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. |
| Expression |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16651-50
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