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Antibody Product Overview
| ELK.No | ES16662 |
| Product name | ESX1 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 80712 |
| Human Swiss-Prot | Q8N693 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ESX1 |
| Fields | >>Signaling pathways regulating pluripotency of stem cells |
| Gene name | ESX1 ESX1L ESX1R |
| Protein name | ESX1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human ESX1 AA range: 327-377 |
| Specificity | This antibody detects endogenous levels of ESX1 at Human |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 45kD |
| Observed band (KD) | |
| Background | This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010], |
| Function | similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Expressed in placenta and testis., |
| Subcellular location | Cytoplasm . Nucleus . ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm. |
| Expression | Expressed in placenta and testis. Expressed in testicular germ cell tumors. |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16662-100
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