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Antibody Product Overview
| ELK.No | ES1673 |
| Product name | APBA2BP rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;IHC;IF;ELISA |
| Other name | NECAB3; APBA2BP; NIP1; SYTIP2; XB51; N-terminal EF-hand calcium-binding protein 3; Amyloid beta A4 protein-binding family A member 2-binding protein; Nek2-interacting protein 1; Neuronal calcium-binding protein 3; X11L-binding protein 51 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 63941 |
| Human Swiss-Prot | Q96P71 |
| Source | Rabbit |
| Isotype | IgG |
| Target | APBA2BP |
| Fields | |
| Gene name | NECAB3 |
| Protein name | N-terminal EF-hand calcium-binding protein 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 56846 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9D6J4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NECAB3. AA range:321-370 |
| Specificity | APBA2BP Polyclonal Antibody detects endogenous levels of APBA2BP protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 44kD |
| Background | The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,function:Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta-amyloid.,PTM:Phosphorylated by NEK2.,similarity:Contains 1 ABM domain.,similarity:Contains 1 EF-hand domain.,subunit:Interacts with the N-terminal domain of APBA2. Interacts with NEK2.,tissue specificity:Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas., |
| Subcellular location | Golgi apparatus . |
| Expression | Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas. |
Additional Images
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Western Blot analysis of various cells using APBA2BP Polyclonal Antibody
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Immunofluorescence analysis of A549 cells, using NECAB3 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from HepG2, COLO, and HT-29 cells, using NECAB3 Antibody. The lane on the right is blocked with the synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
: AO-06-ES1673-100
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