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Antibody Product Overview
| ELK.No | ES16756 |
| Product name | EMAL4 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 27436 |
| Human Swiss-Prot | Q9HC35 |
| Source | Rabbit |
| Isotype | IgG |
| Target | EMAL4 |
| Fields | >>Pathways in cancer;>>Non-small cell lung cancer;>>PD-L1 expression and PD-1 checkpoint pathway in cancer |
| Gene name | EML4 C2orf2 EMAPL4 |
| Protein name | EMAL4 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 78798 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3UMY5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human EMAL4 AA range: 398-448 |
| Specificity | This antibody detects endogenous levels of EMAL4 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 108kD |
| Observed band (KD) | |
| Background | This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015], |
| Function | developmental stage:Strongly overexpressed during mitosis.,function:May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.,similarity:Belongs to the WD repeat EMAP family.,similarity:Contains 9 WD repeats., |
| Subcellular location | Cytoplasm, cytoskeleton . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center . Midbody . Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis. . |
| Expression |
Additional Images
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Western blot analysis of lysates from Jarkat cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16756-50
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