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Antibody Product Overview
| ELK.No | ES16994 |
| Product name | DCK rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1633 |
| Human Swiss-Prot | P27707 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DCK |
| Fields | >>Purine metabolism;>>Pyrimidine metabolism;>>Metabolic pathways;>>Nucleotide metabolism |
| Gene name | DCK |
| Protein name | DCK |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13178 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P43346 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 79127 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P48769 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human DCK AA range: 62-112 |
| Specificity | This antibody detects endogenous levels of DCK at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 29kD |
| Observed band (KD) | |
| Background | Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:NTP + deoxycytidine = NDP + dCMP.,function:Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DCK/DGK family.,subunit:Homodimer., |
| Subcellular location | Nucleus . |
| Expression |
Additional Images
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Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES16994-50
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