Français
English
Antibody Product Overview
| ELK.No | ES17163 |
| Product name | CYBR1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 79901 |
| Human Swiss-Prot | Q53TN4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CYBR1 |
| Fields | >>Mineral absorption |
| Gene name | CYBRD1 DCYTB FRRS3 |
| Protein name | CYBR1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 73649 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q925G2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 295669 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5RKJ2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human CYBR1 AA range: 41-91 |
| Specificity | This antibody detects endogenous levels of CYBR1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 31kD |
| Observed band (KD) | |
| Background | This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008], |
| Function | cofactor:Binds 2 heme groups non-covalently.,disease:Defects in CYBRD1 may be a cause of primary hereditary hemochromatosis (HFE). HFE is an iron-loading disorder characterized by iron accumulation in parenchymal cells. Iron accumulation usually results in tissue damage and causes cirrhosis of the liver, diabetes mellitus, arthropathy, cardiomyopathy, endocrine abnormalities and an increased risk of hepatocellular carcinoma.,function:Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.,induction:By iron deficiency (at protein level).,similarity:Contains 1 cytochrom |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Localized at the brush border of duodenal cells. . |
| Expression | Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium. |
Additional Images
No image
Western blot analysis of lysates from 3T3 cells, primary antibody was diluted at 1:1000, 4°over night
No image
No image
No image
: AO-06-ES17163-100
: 10 Items
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package