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Antibody Product Overview
| ELK.No | ES17224 |
| Product name | CRGC rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1420 |
| Human Swiss-Prot | P07315 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CRGC |
| Fields | |
| Gene name | CRYGC CRYG3 |
| Protein name | CRGC |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12966 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q61597 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24277 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P02529 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human CRGC AA range: 45-95 |
| Specificity | This antibody detects endogenous levels of CRGC at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 19kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. [provided by RefSeq, Jan 2015], |
| Function | disease:Crystallins do not turn over as the lens ages, providing ample opportunity for post-translational modifications or oxidations. These modifications may change crystallin solubility properties and favor senile cataract.,disease:Defects in CRYGC are a cause of autosomal dominant cataract [MIM:604219]. Cataract is an opacification of the eye lens that frequently results in visual impairment or blindness during infancy and early childhood.,disease:Defects in CRYGC are a cause of Coppock-like cataract (CCL) [MIM:604307]. The Coppock cataract refers to a congenital pulverulent disk-like opacity involving the embryonal and fetal nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited.,disease:Defects in CRYGC are the cause of variable zonular pulverulent cataract [MIM:123680].,domain:Has a two-domain beta-structure, folded i |
| Subcellular location | nucleus,cytoplasm, |
| Expression |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES17224-100
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