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Antibody Product Overview
| ELK.No | ES17297 |
| Product name | COTL1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 23406 |
| Human Swiss-Prot | Q14019 |
| Source | Rabbit |
| Isotype | IgG |
| Target | COTL1 |
| Fields | |
| Gene name | COTL1 CLP |
| Protein name | COTL1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 72042 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CQI6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 361422 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | B0BNA5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human COTL1 AA range: 29-79 |
| Specificity | This antibody detects endogenous levels of COTL1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 16kD |
| Observed band (KD) | |
| Background | This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008], |
| Function | function:Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization.,similarity:Belongs to the actin-binding proteins ADF family. Coactosin subfamily.,similarity:Contains 1 ADF-H domain.,subunit:Interacts with 5-lipoxygenase (5LO) in a calcium-independent manner.,tissue specificity:Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas., |
| Subcellular location | Cytoplasm . Cytoplasm, cytoskeleton . Nucleus . |
| Expression | Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. |
Additional Images
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Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES17297-50
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