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Antibody Product Overview
| ELK.No | ES1766 |
| Product name | BCSC-1 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | VWA5A; BCSC1; LOH11CR2A; von Willebrand factor A domain-containing protein 5A; Breast cancer suppressor candidate 1; BCSC-1; Loss of heterozygosity 11 chromosomal region 2 gene A protein |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 4013 |
| Human Swiss-Prot | O00534 |
| Source | Rabbit |
| Isotype | IgG |
| Target | BCSC-1 |
| Fields | |
| Gene name | VWA5A |
| Protein name | von Willebrand factor A domain-containing protein 5A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q99KC8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LHR2A. AA range:371-420 |
| Specificity | BCSC-1 Polyclonal Antibody detects endogenous levels of BCSC-1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 86kD |
| Background | VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. Existing as four alternatively spliced isoforms, the gene encoding VWA5A maps to human chromosome 11q24.2. |
| Function | |
| Subcellular location | nucleus,nucleoplasm, |
| Expression | Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested. |
Additional Images
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Western Blot analysis of various cells using BCSC-1 Polyclonal Antibody
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Western blot analysis of lysates from 293 cells, using LHR2A Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES1766-100
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