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Antibody Product Overview
| ELK.No | ES1780 |
| Product name | BMP-8A rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | BMP8A; Bone morphogenetic protein 8A; BMP-8A |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 353500 |
| Human Swiss-Prot | Q7Z5Y6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | BMP-8A |
| Fields | >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Thermogenesis |
| Gene name | BMP8A |
| Protein name | Bone morphogenetic protein 8A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P34821 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BMP8A. AA range:253-302 |
| Specificity | BMP-8A Polyclonal Antibody detects endogenous levels of BMP-8A protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 45-55kD |
| Background | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016], |
| Function | function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 8A entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked., |
| Subcellular location | Secreted . |
| Expression | Brain,Hippocampus,Thyroid gland, |
Additional Images
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Western Blot analysis of various cells using BMP-8A Polyclonal Antibody
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Western Blot analysis of COLO205 cells using BMP-8A Polyclonal Antibody
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Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
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Immunofluorescence analysis of A549 cells, using BMP8A Antibody. The picture on the right is blocked with the synthesized peptide.
: AO-06-ES1780-100
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