Français
English
Antibody Product Overview
| ELK.No | ES17854 |
| Product name | CASC3 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 22794 |
| Human Swiss-Prot | O15234 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CASC3 |
| Fields | >>Nucleocytoplasmic transport;>>mRNA surveillance pathway |
| Gene name | CASC3 MLN51 |
| Protein name | CASC3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 192160 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8K3W3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 259170 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q8K3X0 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human CASC3 AA range: 434-484 |
| Specificity | This antibody detects endogenous levels of CASC3 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 77kD |
| Observed band (KD) | |
| Background | The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008], |
| Function | domain:The coiled coil domain may be involved in oligomerization.,function:Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport.,PTM:Phosphorylated.,subcellular location:Predominantly found in the perinuclear region (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner.,subunit:Interacts with STAU in an RNA-dependent manner (By similarity). Forms homo-oligomers.,tissue specificity:Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers., |
| Subcellular location | Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Nucleus speckle . Cytoplasm, Stress granule . Cytoplasm, Cytoplasmic ribonucleoprotein granule . Cell projection, dendrite . Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:15166247). In nuclear speckles, colocalizes with MAGOH. Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (PubMed:17652158). In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (By similarity). . |
| Expression | Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers. |
Additional Images
No image
Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
No image
No image
No image
: AO-06-ES17854-50
: 10 Items
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package