Français
English
Antibody Product Overview
| ELK.No | ES1789 |
| Product name | BRCAA1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | ARID4B; BRCAA1; RBBP1L1; RBP1L1; SAP180; AT-rich interactive domain-containing protein 4B; ARID domain-containing protein 4B; 180 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p180; Breast cancer-associated antigen BRCAA1; Hi |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 51742 |
| Human Swiss-Prot | Q4LE39 |
| Source | Rabbit |
| Isotype | IgG |
| Target | BRCAA1 |
| Fields | |
| Gene name | ARID4B |
| Protein name | AT-rich interactive domain-containing protein 4B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 94246 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | A2CG63 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 84481 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9JKB5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BRCAA1. AA range:761-810 |
| Specificity | BRCAA1 Polyclonal Antibody detects endogenous levels of BRCAA1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 148kD |
| Background | This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008], |
| Function | domain:The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.,domain:The C-terminus mediates interaction with mSin3A corepressor complex.,domain:The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.,function:Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,similarity:Contains 1 ARID domain.,subcellular location:Cytoplasmic in breast cancer cells.,subunit:Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.,tissue specificity:Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary., |
| Subcellular location | Nucleus . Cytoplasm . Cytoplasmic in breast cancer cells. . |
| Expression | Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary. |
Additional Images
No image
Western Blot analysis of various cells using BRCAA1 Polyclonal Antibody
No image
Western blot analysis of lysate from HUVEC cells, using BRCAA1 antibody.
No image
No image
: AO-06-ES1789-50
: 10 Items
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package