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Antibody Product Overview
| ELK.No | ES1796 |
| Product name | BST-1 rabbit pAb |
| Reactivity | Human;Mouse;Rat;Monkey |
| Applications | WB;ELISA |
| Other name | BST1; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST-1; Cyclic ADP-ribose hydrolase 2; cADPr hydrolase 2; CD antigen CD157 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 683 |
| Human Swiss-Prot | Q10588 |
| Source | Rabbit |
| Isotype | IgG |
| Target | BST-1 |
| Fields | >>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Salivary secretion;>>Pancreatic secretion |
| Gene name | BST1 |
| Protein name | ADP-ribosyl cyclase 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12182 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q64277 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 81506 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q63072 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BST1. AA range:71-120 |
| Specificity | BST-1 Polyclonal Antibody detects endogenous levels of BST-1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 34kD |
| Background | Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,disease:Rheumatoid arthritis (RA) patients show enhanced expression of BST-1 transcripts in bone marrow stromal cell lines. This suggests that BST-1 overexpression may play a role in B-cell abnormalities in RA.,function:Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.,similarity:Belongs to the ADP-ribosyl cyclase family.,subunit:Homodimer.,tissue specificity:Widely expressed., |
| Subcellular location | Cell membrane; Lipid-anchor, GPI-anchor. |
| Expression | Widely expressed. |
Additional Images
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Western Blot analysis of various cells using BST-1 Polyclonal Antibody
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Western blot analysis of lysates from COS7 and Jurkat cells, using BST1 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES1796-50
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