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Antibody Product Overview
| ELK.No | ES18234 |
| Product name | ASCC3 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10973 |
| Human Swiss-Prot | Q8N3C0 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ASCC3 |
| Fields | |
| Gene name | ASCC3 HELIC1 |
| Protein name | ASCC3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 77987 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | E9PZJ8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | F1LPQ2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human ASCC3 AA range: 2053-2103 |
| Specificity | This antibody detects endogenous levels of ASCC3 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 242kD |
| Observed band (KD) | |
| Background | This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013], |
| Function | function:Enhances NF-kappa-B, SRF and AP1 transactivation.,similarity:Belongs to the helicase family.,similarity:Contains 2 helicase ATP-binding domains.,similarity:Contains 2 helicase C-terminal domains.,similarity:Contains 3 SEC63 domains.,subunit:Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3.,tissue specificity:Ubiquitous., |
| Subcellular location | Nucleus . Nucleus speckle . Cytoplasm, cytosol . Colocalizes with ALKBH3 and ASCC2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. . |
| Expression | Ubiquitous. |
Additional Images
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Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES18234-50
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