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Antibody Product Overview
| ELK.No | ES18242 |
| Product name | ARY2 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10 |
| Human Swiss-Prot | P11245 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ARY2 |
| Fields | >>Caffeine metabolism;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Chemical carcinogenesis - DNA adducts |
| Gene name | NAT2 AAC2 |
| Protein name | ARY2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 17961 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P50295 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 116632 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P50298 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human ARY2 AA range: 80-130 |
| Specificity | This antibody detects endogenous levels of ARY2 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 32kD |
| Observed band (KD) | |
| Background | This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.,disease:Genetic variations in NAT2 determine N-acetylation polymorphism by a low or high NAT activity in the liver [MIM:243400]. It has been implicated in the action and toxicity of amine-containing drugs, and in the susceptibility to bladder cancer and systemic lupus erythematosus. This isozyme is responsible for this polymorphism.,function:Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.,online information:NAT alleles,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the arylamine N-acetyltransferase family., |
| Subcellular location | Cytoplasm. |
| Expression |
Additional Images
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Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES18242-50
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