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Antibody Product Overview
| ELK.No | ES18366 |
| Product name | AMRP rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4043 |
| Human Swiss-Prot | P30533 |
| Source | Rabbit |
| Isotype | IgG |
| Target | AMRP |
| Fields | >>Cholesterol metabolism |
| Gene name | LRPAP1 A2MRAP |
| Protein name | AMRP |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 16976 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P55302 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 116565 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q99068 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human AMRP AA range: 277-327 |
| Specificity | This antibody detects endogenous levels of AMRP at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 39kD |
| Observed band (KD) | |
| Background | This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013], |
| Function | disease:In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.,function:Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.,PTM:N-glycosylated.,similarity:Belongs to the alpha-2-MRAP family.,subcellular location:Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum.,subunit:Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation., |
| Subcellular location | Rough endoplasmic reticulum lumen . Endoplasmic reticulum-Golgi intermediate compartment lumen . Golgi apparatus, cis-Golgi network . Golgi apparatus lumen . Endosome lumen . Cell surface . May be associated with receptors at the cell surface. . |
| Expression |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES18366-50
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