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Antibody Product Overview
| ELK.No | ES18427 |
| Product name | AIP rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9049 |
| Human Swiss-Prot | O00170 |
| Source | Rabbit |
| Isotype | IgG |
| Target | AIP |
| Fields | >>Cushing syndrome;>>Chemical carcinogenesis - receptor activation |
| Gene name | AIP XAP2 |
| Protein name | AIP |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 11632 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O08915 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 282827 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5FWY5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human AIP AA range: 251-301 |
| Specificity | This antibody detects endogenous levels of AIP at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 36kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014], |
| Function | disease:Defects in AIP are a cause of ACTH-secreting pituitary adenoma [MIM:219090]; also known as pituitary Cushing disease. Cushing disease is a condition associated with increased blood cortisol resulting from adrenocorticotropic hormone (ACTH)-producing pituitary tumors that are resistant to glucocorticoid negative feedback.,disease:Defects in AIP are a cause of familial isolated pituitary adenoma (FIPA) [MIM:102200].,disease:Defects in AIP are a cause of growth hormone-secreting pituitary adenoma [MIM:102200]; also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma.,disease:Defects in AIP are a cause of pituitary adenoma predisposition (PAP) [MIM:102200].,function:Cellular negative regulator of the hepatitis B virus (HBV) X protein.,function:May play a positive role in AHR-m |
| Subcellular location | Cytoplasm. |
| Expression | Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver. |
Additional Images
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Western blot analysis of lysates from VEC cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES18427-50
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