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Antibody Product Overview
| ELK.No | ES18456 |
| Product name | ADCY5 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 111 |
| Human Swiss-Prot | O95622 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ADCY5 |
| Fields | >>Purine metabolism;>>Metabolic pathways;>>Endocrine resistance;>>Rap1 signaling pathway;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>Phospholipase D signaling pathway;>>Oocyte meiosis;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Adrenergic signaling in cardiomyocytes;>>Vascular smooth muscle contraction;>>Apelin signaling pathway;>>Gap junction;>>Platelet activation;>>Circadian entrainment;>>Thermogenesis;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Cholinergic synapse;>>Serotonergic synapse;>>GABAergic synapse;>>Dopaminergic synapse;>>Inflammatory mediator regulation of TRP channels;>>Insulin secretion;>>GnRH signaling pathway;>>Ovarian steroidogenesis;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Melanogenesis;>>Thyroid hormone synthesis;>>Oxytocin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Aldosterone synthesis and secretio |
| Gene name | ADCY5 |
| Protein name | ADCY5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 224129 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P84309 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 64532 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q04400 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human ADCY5 AA range: 471-521 |
| Specificity | This antibody detects endogenous levels of ADCY5 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 139kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010], |
| Function | catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Inhibition by calcium in the submicromolar concentration range.,function:This is a membrane-bound, calcium-inhibitable adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein. Cell projection, cilium . |
| Expression | Detected in pancreas islets (at protein level). Detected in pancreas islets. |
Additional Images
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Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES18456-50
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