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Antibody Product Overview
| ELK.No | ES1897 |
| Product name | CD172b rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | SIRPB1; Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD antigen CD172b |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 10326 |
| Human Swiss-Prot | O00241 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CD172b |
| Fields | >>Osteoclast differentiation |
| Gene name | SIRPB1 |
| Protein name | Signal-regulatory protein beta-1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SIRPB1. AA range:231-280 |
| Specificity | CD172b Polyclonal Antibody detects endogenous levels of CD172b protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 48kD |
| Background | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009], |
| Function | function:Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.,function:Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.,PTM:N-glycosylated.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C1-type (immunoglobulin-like) domains.,subunit:Interacts with TYROBP. This interaction results in the recruitment of SYK.,tissue specificity:Detected in monocytes and dendritic cells., |
| Subcellular location | Cell membrane ; Single-pass type I membrane protein . |
| Expression | Detected in monocytes and dendritic cells. |
Additional Images
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Western Blot analysis of various cells using CD172b Polyclonal Antibody
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Western blot analysis of lysates from HeLa, COLO, and HUVEC cells, using SIRPB1 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES1897-100
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