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Antibody Product Overview
| ELK.No | ES1925 |
| Product name | Cdc23 rabbit pAb |
| Reactivity | Human;Mouse;Monkey |
| Applications | WB;ELISA |
| Other name | CDC23; ANAPC8; Cell division cycle protein 23 homolog; Anaphase-promoting complex subunit 8; APC8; Cyclosome subunit 8 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8697 |
| Human Swiss-Prot | Q9UJX2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Cdc23 |
| Fields | >>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>Progesterone-mediated oocyte maturation;>>Human T-cell leukemia virus 1 infection |
| Gene name | CDC23 |
| Protein name | Cell division cycle protein 23 homolog |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 52563 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8BGZ4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human APC8. AA range:251-300 |
| Specificity | Cdc23 Polyclonal Antibody detects endogenous levels of Cdc23 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 69kD |
| Background | The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008], |
| Function | function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Thr-556 occurs specifically during mitosis.,similarity:Belongs to the APC8/CDC23 family.,similarity:Contains 9 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits., |
| Subcellular location | intracellular,nucleoplasm,anaphase-promoting complex,cytosol, |
| Expression | Bone marrow,Brain,Duodenum,Epithelium,Pancreas,Placenta, |
Additional Images
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Western Blot analysis of various cells using Cdc23 Polyclonal Antibody diluted at 1:2000
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Western Blot analysis of COS7 cells using Cdc23 Polyclonal Antibody diluted at 1:2000
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: AO-06-ES1925-50
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