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Antibody Product Overview
| ELK.No | ES1975 |
| Product name | Choactase rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | CHAT; Choline O-acetyltransferase; CHOACTase; ChAT; Choline acetylase |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1103 |
| Human Swiss-Prot | P28329 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Choactase |
| Fields | >>Glycerophospholipid metabolism;>>Cholinergic synapse |
| Gene name | CHAT |
| Protein name | Choline O-acetyltransferase |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q03059 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P32738 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Choactase. AA range:334-383 |
| Specificity | Choactase Polyclonal Antibody detects endogenous levels of Choactase protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 82,70kD |
| Background | This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010], |
| Function | catalytic activity:Acetyl-CoA + choline = CoA + O-acetylcholine.,disease:Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement.,function:Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.,online information:Choline acetyltransferase entry,similarity:Belongs to the carnitine/choline acetyltransferase family., |
| Subcellular location | nucleus,cytoplasm,cytosol,presynapse, |
| Expression | Brain,Lymphocyte,Placenta,Spinal cord, |
Additional Images
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Western Blot analysis of various cells using Choactase Polyclonal Antibody diluted at 1:1000
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Western blot analysis of lysate from HepG2 cells, using Choactase antibody.
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: AO-06-ES1975-50
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