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Antibody Product Overview
| ELK.No | ES1992 |
| Product name | CLC-6 rabbit pAb |
| Reactivity | Human;Mouse;Rat;Monkey |
| Applications | WB;ELISA |
| Other name | CLCN6; KIAA0046; Chloride transport protein 6; Chloride channel protein 6; ClC-6 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1185 |
| Human Swiss-Prot | P51797 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CLC-6 |
| Fields | |
| Gene name | CLCN6 |
| Protein name | Chloride transport protein 6 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 26372 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O35454 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CLCN6. AA range:611-660 |
| Specificity | CLC-6 Polyclonal Antibody detects endogenous levels of CLC-6 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 97kD |
| Background | chloride voltage-gated channel 6(CLCN6) Homo sapiens This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012], |
| Function | function:Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.,miscellaneous:The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.,PTM:N-glycosylated on several asparagine residues.,similarity:Belongs to the chloride channel (TC 2.A.49) family.,similarity:Contains 2 CBS domains.,subcellular location:Detected in detergent-resistant lipid rafts.,tissue specificity:Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform C is only detected in kidney., |
| Subcellular location | Late endosome membrane ; Multi-pass membrane protein . |
| Expression | Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney. |
Additional Images
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Western Blot analysis of various cells using CLC-6 Polyclonal Antibody diluted at 1:500
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Western Blot analysis of L929 cells using CLC-6 Polyclonal Antibody diluted at 1:500
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Western blot analysis of lysates from COS7 and HT-29 cells, using CLCN6 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES1992-50
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