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Antibody Product Overview
| ELK.No | ES20782 |
| Product name | CNTF rabbit pAb |
| Reactivity | Human;Rat;Mouse |
| Applications | WB |
| Other name | CNTF; Ciliary neurotrophic factor; CNTF |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1270 |
| Human Swiss-Prot | P26441 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CNTF |
| Fields | >>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway |
| Gene name | CNTF |
| Protein name | Ciliary neurotrophic factor (CNTF) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P51642 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P20294 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthetic Peptide of CNTF |
| Specificity | CNTF protein(A218) detects endogenous levels of CNTF |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-1000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 30kD |
| Background | The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010], |
| Function | disease:Overexpressed in most acute myelogenous leukemia (AML) cases (27 over 29).,function:CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.,function:May be involved in transcriptional regulation. May play an important role in cell proliferation and/or anti-apoptosis.,online information:Ciliary neurotrophic factor entry,similarity:Belongs to the CNTF family.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subunit:Homodimer.,tissue specificity:Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.,tissue specificity:Nervous system., |
| Subcellular location | Cytoplasm. |
| Expression | Nervous system. |
Additional Images
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Western blot analysis of 1) Hela, 2)Mouse Brain Tissue, 3)Rat Brain Tissue with CNTF Rabbit pAb diluted at 1:2,000.
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: AO-06-ES20782-100
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