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Antibody Product Overview
| ELK.No | ES20862 |
| Product name | ATG13 Rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | IHC;WB |
| Other name | Autophagy-related protein 13 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 9776 |
| Human Swiss-Prot | O75143 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ATG13 |
| Fields | >>Autophagy - other;>>Autophagy - animal;>>Longevity regulating pathway;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases |
| Gene name | ATG13 KIAA0652 |
| Protein name | ATG13 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 51897 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q91YI1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human ATG13 AA range: 182-232 |
| Specificity | This antibody detects endogenous levels of ATG13 at Human, Mouse,Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.19% sodium azide. |
| Clonality | Polyclonal |
| Dilution | IHC-p1:50-200 ,WB 1:1000-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 72kD |
| Background | Atg13 was identified as a constitutively expressed protein that was genetically linked to Atg1/Apg1, a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions. |
| Function | |
| Subcellular location | Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. . |
| Expression |
Additional Images
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Western blot analysis of 1)Hela Cell, 2) Rat Brain Tissue, 3) Mouse Brainr Tissue Lysate using Rabbit pAb diluted at 1:2,000.
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES20862-100
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