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Antibody Product Overview
| ELK.No | ES2105 |
| Product name | CYP2S1 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;IHC;IF;ELISA |
| Other name | CYP2S1; Cytochrome P450 2S1; CYPIIS1 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 29785 |
| Human Swiss-Prot | Q96SQ9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CYP2S1 |
| Fields | >>Retinol metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Metabolic pathways |
| Gene name | CYP2S1 |
| Protein name | Cytochrome P450 2S1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 74134 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9DBX6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2S1. AA range:181-230 |
| Specificity | CYP2S1 Polyclonal Antibody detects endogenous levels of CYP2S1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 56kD |
| Background | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Has a potential importance for extrahepatic xenobiotic metabolism.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:High level of expression in trachea, lung, stomach, small intestine, and spleen., |
| Subcellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein . |
| Expression | Expressed at higher levels in extrahepatic tissues including trachea, lung, stomach, small intestine, colon, kidney, breast, placenta and spleen (PubMed:11181079, PubMed:12711469). Expressed in peripheral blood leukocytes (PubMed:11181079). Constitutively expressed in skin (at protein level) (PubMed:12711469). |
Additional Images
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Western Blot analysis of various cells using CYP2S1 Polyclonal Antibody diluted at 1:2000
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Immunofluorescence analysis of A549 cells, using Cytochrome P450 2S1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Cytochrome P450 2S1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from HUVEC and COLO cells, using Cytochrome P450 2S1 Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES2105-100
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