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Antibody Product Overview
| ELK.No | ES2139 |
| Product name | Dab1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | DAB1; Disabled homolog 1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1600 |
| Human Swiss-Prot | O75553 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Dab1 |
| Fields | >>Spinocerebellar ataxia |
| Gene name | DAB1 |
| Protein name | Disabled homolog 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13131 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P97318 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 266729 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q8CJH2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Dab1. AA range:199-248 |
| Specificity | Dab1 Polyclonal Antibody detects endogenous levels of Dab1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008], |
| Function | domain:The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.,function:Adapter molecule functioning in neural development. May regulate SIAH1 activity.,PTM:Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser-524 independently of reelin signaling.,similarity:Contains 1 PID domain.,subunit:Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity). Interacts with LRP1., |
| Subcellular location | nucleolus,microtubule organizing center,cytosol,brush border,postsynaptic density,membrane,neuron projection,neuronal cell body,intracellular membrane-bounded organelle,apical part of cell,perinuclear region of cytoplasm, |
| Expression | Mainly expressed in brain. |
Additional Images
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Western Blot analysis of various cells using Dab1 Polyclonal Antibody
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Western Blot analysis of 293 cells using Dab1 Polyclonal Antibody
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Immunofluorescence analysis of MCF7 cells, using Dab1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from HepG2 and 293 cells, using Dab1 Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES2139-50
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