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Antibody Product Overview
| ELK.No | ES2152 |
| Product name | DcR3 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | TNFRSF6B; DCR3; TR6; Tumor necrosis factor receptor superfamily member 6B; Decoy receptor 3; DcR3; Decoy receptor for Fas ligand; M68 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 8771 |
| Human Swiss-Prot | O95407 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DcR3 |
| Fields | >>Cytokine-cytokine receptor interaction |
| Gene name | TNFRSF6B |
| Protein name | Tumor necrosis factor receptor superfamily member 6B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNFRSF6B. AA range:251-300 |
| Specificity | DcR3 Polyclonal Antibody detects endogenous levels of DcR3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 32kD |
| Background | This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011], |
| Function | alternative products:Additional isoforms seem to exist,function:ATP-dependent DNA helicase required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by promoting the disassembly of D loop recombination intermediates. Also required to regulate telomere length; probably due to its anti-recombinase function.,function:Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against apoptosis.,miscellaneous:Amplified in gastric tumors.,similarity:Belongs to the helicase family. RAD3/XPD subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 4 TNFR-Cys repeats.,tissue specificity:Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed |
| Subcellular location | Secreted. |
| Expression | Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. |
Additional Images
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Western Blot analysis of various cells using DcR3 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Western blot analysis of TNFRSF6B Antibody. The lane on the right is blocked with the TNFRSF6B peptide.
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Immunohistochemistryt analysis of paraffin-embedded human colon t carcinoma, using TNFRSF6B Antibody. The lane on the right is blocked with the TNFRSF6B peptide.
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Immunofluorescence analysis of TNFRSF6B Antibody. The lane on the right is blocked with the TNFRSF6B peptide.
: AO-06-ES2152-100
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