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Antibody Product Overview
| ELK.No | ES2190 |
| Product name | DOC-1 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | CDK2AP1; CDKAP1; DOC1; Cyclin-dependent kinase 2-associated protein 1; CDK2-associated protein 1; Deleted in oral cancer 1; DOC-1; Putative oral cancer suppressor |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 8099 |
| Human Swiss-Prot | O14519 |
| Source | Rabbit |
| Isotype | IgG |
| Target | DOC-1 |
| Fields | |
| Gene name | CDK2AP1 |
| Protein name | Cyclin-dependent kinase 2-associated protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13445 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O35207 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDKAP1. AA range:51-100 |
| Specificity | DOC-1 Polyclonal Antibody detects endogenous levels of DOC-1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 20kD |
| Background | cyclin dependent kinase 2 associated protein 1(CDK2AP1) Homo sapiens The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012], |
| Function | similarity:Belongs to the CDK2AP family., |
| Subcellular location | nucleus,perinuclear region of cytoplasm, |
| Expression | Skin,Testis, |
Additional Images
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Western Blot analysis of various cells using DOC-1 Polyclonal Antibody diluted at 1:500
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Western blot analysis of lysates from HeLa cells, using CDKPA1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HeLa cells using CDKAP1 antibody.
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: AO-06-ES2190-100
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