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Antibody Product Overview
| ELK.No | ES2272 |
| Product name | EphA5 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | EPHA5; BSK; EHK1; HEK7; TYRO4; Ephrin type-A receptor 5; Brain-specific kinase; EPH homology kinase 1; EHK-1; EPH-like kinase 7; EK7; hEK7 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2044 |
| Human Swiss-Prot | P54756 |
| Source | Rabbit |
| Isotype | IgG |
| Target | EphA5 |
| Fields | >>Axon guidance |
| Gene name | EPHA5 |
| Protein name | Ephrin type-A receptor 5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13839 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q60629 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 79208 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P54757 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EPHA5. AA range:471-520 |
| Specificity | EphA5 Polyclonal Antibody detects endogenous levels of EphA5 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 110kD |
| Background | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013], |
| Function | alternative products:Additional isoforms seem to exist,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Almost exclusively expressed in the nervous system., |
| Subcellular location | Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . |
| Expression | Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord. |
Additional Images
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Western Blot analysis of various cells using EphA5 Polyclonal Antibody
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Western Blot analysis of A549 cells using EphA5 Polyclonal Antibody
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Western blot analysis of the lysates from HeLa cells using EPHA5 antibody.
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: AO-06-ES2272-50
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