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Antibody Product Overview
| ELK.No | ES2328 |
| Product name | FAST rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | FASTK; Fas-activated serine/threonine kinase; FAST kinase |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10922 |
| Human Swiss-Prot | Q14296 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FAST |
| Fields | |
| Gene name | FASTK |
| Protein name | Fas-activated serine/threonine kinase |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9JIX9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FAST. AA range:361-410 |
| Specificity | FAST Polyclonal Antibody detects endogenous levels of FAST protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 61kD |
| Background | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein].,function:Fas-mediated apoptosis is characterized by FASTK-dephosphorylation and TIA-1-phosphorylation. Both are activated and FASTK-mediated TIA-1 activation play a key role in apoptosis.,PTM:Phosphorylated on serine/threonine.,similarity:Belongs to the FAST protein kinase family.,similarity:Contains 1 RAP domain.,subunit:Interacts with TIA-1.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas., |
| Subcellular location | [Isoform 4]: Mitochondrion matrix . Colocalizes with mitochondrial RNA granules. . |
| Expression | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
Additional Images
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Western Blot analysis of various cells using FAST Polyclonal Antibody
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Western blot analysis of lysate from A549 cells, using FAST antibody.
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: AO-06-ES2328-50
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