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Antibody Product Overview
| ELK.No | ES2334 |
| Product name | FBP2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | KHSRP; FUBP2; Far upstream element-binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; p75 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8570 |
| Human Swiss-Prot | Q92945 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FBP2 |
| Fields | |
| Gene name | KHSRP |
| Protein name | Far upstream element-binding protein 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 16549 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3U0V1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 171137 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q99PF5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from the N-terminal region of human FBP2. |
| Specificity | FBP2 Polyclonal Antibody detects endogenous levels of FBP2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 73kD |
| Background | The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010], |
| Function | function:Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the KHSRP family.,similarity:Contains 4 KH domains.,subcellular location:A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.,subunit:Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and |
| Subcellular location | Nucleus . Cytoplasm . A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. . |
| Expression | Detected in neural and non-neural cell lines. |
Additional Images
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Western Blot analysis of various cells using FBP2 Polyclonal Antibody
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Western Blot analysis of HuvEc cells using FBP2 Polyclonal Antibody
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: AO-06-ES2334-50
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