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Antibody Product Overview
| ELK.No | ES2377 |
| Product name | FRS3 rabbit pAb |
| Reactivity | Human;Monkey |
| Applications | WB;ELISA |
| Other name | FRS3; Fibroblast growth factor receptor substrate 3; FGFR substrate 3; FGFR-signaling adaptor SNT2; Suc1-associated neurotrophic factor target 2; SNT-2 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 10817 |
| Human Swiss-Prot | O43559 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FRS3 |
| Fields | |
| Gene name | FRS3 |
| Protein name | Fibroblast growth factor receptor substrate 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q91WJ0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FRS3. AA range:191-240 |
| Specificity | FRS3 Polyclonal Antibody detects endogenous levels of FRS3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 54kD |
| Background | This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013], |
| Function | function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.,PTM:Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.,similarity:Contains 1 IRS-type PTB domain.,subunit:Binds NTRK1 (By similarity). Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2., |
| Subcellular location | Membrane; Lipid-anchor. |
| Expression | Brain,Placenta, |
Additional Images
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Western Blot analysis of various cells using FRS3 Polyclonal Antibody
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Western blot analysis of lysates from COS7 cells, using FRS3 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES2377-100
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