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Antibody Product Overview
| ELK.No | ES2387 |
| Product name | GABAA Rα4 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | GABRA4; Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2557 |
| Human Swiss-Prot | P48169 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GABA A Receptor α4 |
| Fields | >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>GABAergic synapse;>>Taste transduction;>>Morphine addiction;>>Nicotine addiction |
| Gene name | GABRA4 |
| Protein name | Gamma-aminobutyric acid receptor subunit alpha-4 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14397 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9D6F4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 140675 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P28471 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GABRA4. AA range:81-130 |
| Specificity | GABAA Rα4 Polyclonal Antibody detects endogenous levels of GABAA Rα4 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011], |
| Function | function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,induction:The alpha4 beta2 gamma 2L receptor is not repressed by diazepam.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho., |
| Subcellular location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Expression | Brain,Brain cortex, |
Additional Images
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Western Blot analysis of various cells using GABAA Rα4 Polyclonal Antibody diluted at 1:1000
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Western blot analysis of GABRA4 Antibody. The lane on the right is blocked with the GABRA4 peptide.
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Western blot analysis of the lysates from COLO205 cells using GABRA4 antibody.
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: AO-06-ES2387-50
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