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Antibody Product Overview
| ELK.No | ES2432 |
| Product name | GLP-1R rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | GLP1R; Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2740 |
| Human Swiss-Prot | P43220 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GLP1R |
| Fields | >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Insulin secretion |
| Gene name | GLP1R |
| Protein name | Glucagon-like peptide 1 receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O35659 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GLP1R. AA range:101-150 |
| Specificity | GLP-1R Polyclonal Antibody detects endogenous levels of GLP-1R protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 53kD |
| Background | glucagon like peptide 1 receptor(GLP1R) Homo sapiens This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016], |
| Function | function:This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,online information:Glucagon-like peptide 1 entry,similarity:Belongs to the G-protein coupled receptor 2 family., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . |
| Expression | Gastric carcinoma,Insulinoma,Pancreas,Pancreatic islet,Placenta, |
Additional Images
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Western Blot analysis of various cells using GLP-1R Polyclonal Antibody
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Western Blot analysis of HepG2 cells using GLP-1R Polyclonal Antibody
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Immunofluorescence analysis of HeLa cells, using GLP1R Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES2432-100
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