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Antibody Product Overview
| ELK.No | ES2434 |
| Product name | Glucosidase IIβ rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;IF;ELISA |
| Other name | PRKCSH; G19P1; Glucosidase 2 subunit beta; 80K-H protein; Glucosidase II subunit beta; Protein kinase C substrate 60.1 kDa protein heavy chain; PKCSH |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5589 |
| Human Swiss-Prot | P14314 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Glucosidase IIβ |
| Fields | >>Protein processing in endoplasmic reticulum |
| Gene name | PRKCSH |
| Protein name | Glucosidase 2 subunit beta |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 19089 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O08795 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GLU2B. AA range:81-130 |
| Specificity | Glucosidase IIβ Polyclonal Antibody detects endogenous levels of Glucosidase IIβ protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 59kD |
| Background | This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014], |
| Function | disease:Defects in PRKCSH are a cause of polycystic liver disease (PCLD) [MIM:174050]. PCLD is an autosomal dominant disorder and is characterized by the presence of multiple liver cysts of biliary epithelial origin. PCLD is a distinct clinical and genetic entity that can occur independently from autosomal dominant polycystic kidney disease (ADPKD) [MIM:173900], which in a considerable but uncertain proportion of cases is associated with hepatic cysts.,function:Regulatory subunit of glucosidase II.,pathway:Glycan metabolism; N-glycan metabolism.,similarity:Contains 1 PRKCSH domain.,similarity:Contains 2 EF-hand domains.,subunit:Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH). Binds glycosylated PTPRC., |
| Subcellular location | Endoplasmic reticulum . |
| Expression | Lung,Lymphocyte,Platelet, |
Additional Images
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Western Blot analysis of various cells using Glucosidase IIβ Polyclonal Antibody
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Western Blot analysis of A549 cells using Glucosidase IIβ Polyclonal Antibody
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Immunofluorescence analysis of HeLa cells, using GLU2B Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from HepG2, 293, and HUVEC cells, using GLU2B Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES2434-50
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