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Antibody Product Overview
| ELK.No | ES2498 |
| Product name | HDAC1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | HDAC1; RPD3L1; Histone deacetylase 1; HD1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3065 |
| Human Swiss-Prot | Q13547 |
| Source | Rabbit |
| Isotype | IgG |
| Target | HDAC1 |
| Fields | >>Cell cycle;>>Longevity regulating pathway - multiple species;>>Notch signaling pathway;>>Neutrophil extracellular trap formation;>>Thyroid hormone signaling pathway;>>Huntington disease;>>Amphetamine addiction;>>Alcoholism;>>Human papillomavirus infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Viral carcinogenesis;>>MicroRNAs in cancer;>>Chronic myeloid leukemia |
| Gene name | HDAC1 |
| Protein name | Histone deacetylase 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 433759 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O09106 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 297893 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q4QQW4 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HDAC1. AA range:387-436 |
| Specificity | HDAC1 Polyclonal Antibody detects endogenous levels of HDAC1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 55kD |
| Background | Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.,PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates |
| Subcellular location | Nucleus . |
| Expression | Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain. |
Additional Images
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Western Blot analysis of various cells using HDAC1 Polyclonal Antibody diluted at 1:500
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Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using HDAC1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from NIH/3T3 cells, using HDAC1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from COLO205 cells using HDAC1 antibody.
: AO-06-ES2498-50
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