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Histone deacetylase 9 rabbit pAb
AO-06-ES2522-50
Antibody Product Overview
| ELK.No | ES2522 |
| Product name | Histone deacetylase 9 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | Histone deacetylase 9; HD9; Histone deacetylase 7B; HD7; HD7b; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; HDAC9; HDAC7; HDAC7B; HDRP; KIAA0744; MITR |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9734 |
| Human Swiss-Prot | Q9UKV0-5,6,7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Histone deacetylase 9 |
| Fields | >>Neutrophil extracellular trap formation;>>Alcoholism;>>Viral carcinogenesis |
| Gene name | HDAC9 |
| Protein name | Histone deacetylase 9 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HDAC9. AA range:1017-1066 |
| Specificity | Histone deacetylase 9 Polyclonal Antibody detects endogenous levels of Histone deacetylase 9 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 110kD |
| Background | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 9 encoded by HDAC9 has sequence homology to members of the histone deacetylase family. HDAC9 is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. |
| Function | |
| Subcellular location | Nucleus . |
| Expression | Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level). |
Additional Images
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Western Blot analysis of various cells using Histone deacetylase 9 Polyclonal Antibody diluted at 1:1000
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Western Blot analysis of HepG2 cells using Histone deacetylase 9 Polyclonal Antibody diluted at 1:1000
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Immunofluorescence analysis of HepG2 cells, using HDAC9 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using HDAC9 Antibody. The picture on the right is blocked with the synthesized peptide.
: AO-06-ES2522-50
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