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Antibody Product Overview
| ELK.No | ES2569 |
| Product name | HSC 70 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | HSPA8; HSC70; HSP73; HSPA10; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3312 |
| Human Swiss-Prot | P11142 |
| Source | Rabbit |
| Isotype | IgG |
| Target | HSC 70 |
| Fields | >>Spliceosome;>>MAPK signaling pathway;>>Protein processing in endoplasmic reticulum;>>Endocytosis;>>Longevity regulating pathway - multiple species;>>Antigen processing and presentation;>>Estrogen signaling pathway;>>Prion disease;>>Legionellosis;>>Toxoplasmosis;>>Measles;>>Lipid and atherosclerosis |
| Gene name | HSPA8 |
| Protein name | Heat shock cognate 71 kDa protein |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 15481 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P63017 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24468 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P63018 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HSC 70. AA range:202-251 |
| Specificity | HSC 70 Polyclonal Antibody detects endogenous levels of HSC 70 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 70kD |
| Background | This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011], |
| Function | function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous., |
| Subcellular location | Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. |
| Expression | Ubiquitous. |
Additional Images
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Western Blot analysis of various cells using HSC 70 Polyclonal Antibody diluted at 1:2000
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Western Blot analysis of HepG2 cells using HSC 70 Polyclonal Antibody diluted at 1:2000
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Western blot analysis of lysate from HeLa cells, using HSC 70 antibody.
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: AO-06-ES2569-100
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