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Antibody Product Overview
| ELK.No | ES2599 |
| Product name | Ikaros 3 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | IKZF3; ZNFN1A3; Zinc finger protein Aiolos; Ikaros family zinc finger protein 3 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 22806 |
| Human Swiss-Prot | Q9UKT9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Ikaros 3 |
| Fields | |
| Gene name | IKZF3 |
| Protein name | Zinc finger protein Aiolos |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 22780 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O08900 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IKZF3. AA range:361-410 |
| Specificity | Ikaros 3 Polyclonal Antibody detects endogenous levels of Ikaros 3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 62kD |
| Background | This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012], |
| Function | function:Transcription factor that plays an important role in the regulation of lymphocyte differentiation.,similarity:Belongs to the Ikaros C2H2-type zinc-finger protein family.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with IKZF4 AND IKZF5.,tissue specificity:Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus., |
| Subcellular location | Nucleus . Cytoplasm .; [Isoform 1]: Nucleus .; [Isoform 3]: Nucleus .; [Isoform 11]: Nucleus .; [Isoform 14]: Nucleus . Cytoplasm .; [Isoform 12]: Cytoplasm . |
| Expression | Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus. |
Additional Images
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Western Blot analysis of various cells using Ikaros 3 Polyclonal Antibody diluted at 1:1000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Western blot analysis of lysates from COLO cells, using IKZF3 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES2599-50
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