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Antibody Product Overview
| ELK.No | ES2614 |
| Product name | IL-21 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | IL21; Interleukin-21; IL-21; Za11 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 59067 |
| Human Swiss-Prot | Q9HBE4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | IL-21 |
| Fields | >>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway;>>Th17 cell differentiation;>>Inflammatory bowel disease |
| Gene name | IL21 |
| Protein name | Interleukin-21 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 60505 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9ES17 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IL21. AA range:91-140 |
| Specificity | IL-21 Polyclonal Antibody detects endogenous levels of IL-21 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 18kD |
| Background | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011], |
| Function | function:Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.,similarity:Belongs to the IL-15/IL-21 family.,tissue specificity:Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes., |
| Subcellular location | Secreted . |
| Expression | Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. |
Additional Images
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Western Blot analysis of various cells using IL-21 Polyclonal Antibody diluted at 1:500
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: AO-06-ES2614-100
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